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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Hypericin, Gemcitabine
Phytochemical Name Hypericin (PubChem CID: 3663 )
Anticancer drug Name Gemcitabine (PubChem CID: 60750 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 431
Ref_1
Pair Name Hypericin, Gemcitabine
Disease Info [ICD-11: 2C10] Pancreatic cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Up-regulation Expression BAX hsa581
Down-regulation Expression BCL2 hsa596
Up-regulation Cleavage CASP3 hsa836
Up-regulation Cleavage CASP9 hsa842
Up-regulation Expression CYCS hsa54205
Down-regulation Expression DCTPP1 hsa79077
Down-regulation Expression H6PD hsa9563
Up-regulation Cleavage PARP1 hsa142
In Vitro Model Capan-2 Pancreatic ductal adenocarcinoma Homo sapiens (Human) CVCL_0026
Result We demonstrated that Gem combined HY-PDT could inhibit the proliferation of Capan-2 cells and induce cell apoptosis. HY-PDT combined with Gem had a great potential on pancreatic cancer treatment clinically.
03. Reference
No. Title Href
1 Hypericin-mediated photodynamic therapy enhances gemcitabine induced Capan-2 cell apoptosis via inhibiting NADPH level. J Pharm Pharmacol. 2022 Apr 20;74(4):596-604. doi: 10.1093/jpp/rgab073. Click
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